Rhodium-catalyzed synthesis of α-amido- and α-carboxylic-β-ketoesters

被引:36
作者
Bertelsen, S [1 ]
Nielsen, M [1 ]
Bachmann, S [1 ]
Jorgensen, KA [1 ]
机构
[1] Aarhus Univ, Ctr Catalysis, Dept Chem, Danish Natl Res Fdn, DK-8000 Aarhus, Denmark
来源
SYNTHESIS-STUTTGART | 2005年 / 13期
关键词
amides; carboxylic acids; catalysis; diazo compounds; insertions; rhodium;
D O I
10.1055/s-2005-869952
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The rhodium-catalyzed N-H and O-H insertion of amides and carboxylic acids with alpha-diazo-beta-ketoesters to give different alpha-amido- and alpha-carboxylic-beta-ketoesters is presented. Investigations were carried out to establish an efficient N-H and O-H insertion reaction using a range of different amides and carboxylic acids for the synthesis of intermediates e.g. for receptor antagonists. The reactions were performed under mild conditions with 1 mol% of catalyst and the products were formed in good yields.
引用
收藏
页码:2234 / 2238
页数:5
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