Rhodium-catalyzed synthesis of α-amido- and α-carboxylic-β-ketoesters

被引：36

作者：

Bertelsen, S ^{[1
]}

Nielsen, M ^{[1
]}

Bachmann, S ^{[1
]}

Jorgensen, KA ^{[1
]}

机构：

[1] Aarhus Univ, Ctr Catalysis, Dept Chem, Danish Natl Res Fdn, DK-8000 Aarhus, Denmark

来源：

SYNTHESIS-STUTTGART | 2005年 / 13期

关键词：

amides; carboxylic acids; catalysis; diazo compounds; insertions; rhodium;

D O I：

10.1055/s-2005-869952

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rhodium-catalyzed N-H and O-H insertion of amides and carboxylic acids with alpha-diazo-beta-ketoesters to give different alpha-amido- and alpha-carboxylic-beta-ketoesters is presented. Investigations were carried out to establish an efficient N-H and O-H insertion reaction using a range of different amides and carboxylic acids for the synthesis of intermediates e.g. for receptor antagonists. The reactions were performed under mild conditions with 1 mol% of catalyst and the products were formed in good yields.

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收藏

页码：2234 / 2238

页数：5

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