Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects

被引：192

作者：

Tang, Siu Wa ^{[1
,2
]}

Chu, Emily ^{[2
]}

Hui, Tomy ^{[2
]}

Helmeste, Daiga ^{[1
]}

Law, Cindy ^{[2
]}

机构：

[1] Univ Calif Irvine, Dept Psychiat, Irvine, CA 92697 USA

[2] Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2008年 / 431卷 / 01期

关键词：

brain-derived neurotrophic factor; serum; exercise; human;

D O I：

10.1016/j.neulet.2007.11.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of short-term exercise (15 min step-exercise) on serum brain-derived neurotrophic factor (BDNF) levels was evaluated in healthy human subjects. Results showed a short-term, significant increase in serum BDNF levels after exercise. Intra-individual differences in serum BDNF levels were remarkably small on the rest day and also when compared to rest values on the day of the exercise test. Inter-individual differences, on the other hand, were larger by comparison. The result of this study supports the need for larger sample size in studies on BDNF changes in psychiatric disorders or psychiatric drug effects. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：62 / 65

页数：4

共 25 条

[1] Variation in levels of serum inhibin B, testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone, and sex hormone-binding globulin in monthly samples from healthy men during a 17-month period:: Possible effects of seasons [J].

Andersson, AM ;

Carlsen, E ;

Petersen, JH ;

Skakkebæk, NE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (02) :932-937

[2] Comparison of proteomic profiles of serum, plasma, and modified media supplements used for cell culture and expansion [J].

Ayache, Saleh ;

Panelli, Monica C. ;

Byrne, Karen M. ;

Slezak, Stefanie ;

Leitman, Susan F. ;

Marincola, Francesco M. ;

Stroncek, David F. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2006, 4 (1)

[3] Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior [J].

Chen, Zhe-Yu ;

Jing, Deqiang ;

Bath, Kevin G. ;

Ieraci, Alessandro ;

Khan, Tanvir ;

Siao, Chia-Jen ;

Herrera, Daniel G. ;

Toth, Miklos ;

Yang, Chingwen ;

McEwen, Bruce S. ;

Hempstead, Barbara L. ;

Lee, Francis S. .

SCIENCE, 2006, 314 (5796) :140-143

[4] Exercise: a behavioral intervention to enhance brain health and plasticity [J].

Cotman, CW ;

Berchtold, NC .

TRENDS IN NEUROSCIENCES, 2002, 25 (06) :295-301

[5] Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes [J].

Cunha, Angelo B. M. ;

Frey, Benicio N. ;

Andreazza, Ana C. ;

Goi, Julia D. ;

Rosa, Adriane R. ;

Goncalves, Carlos A. ;

Santin, Aida ;

Kapczinski, Flavio .

NEUROSCIENCE LETTERS, 2006, 398 (03) :215-219

[6] Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls [J].

Gold, SM ;

Schulz, KH ;

Hartmann, S ;

Mladek, M ;

Lang, UE ;

Hellweg, R ;

Reer, R ;

Braumann, KM ;

Heesen, C .

JOURNAL OF NEUROIMMUNOLOGY, 2003, 138 (1-2) :99-105

[7] Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets [J].

Karege, F ;

Schwald, M ;

Cisse, M .

NEUROSCIENCE LETTERS, 2002, 328 (03) :261-264

[8] Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity [J].

Karege, F ;

Bondolfi, G ;

Gervasoni, N ;

Schwald, M ;

Aubry, JM ;

Bertschy, G .

BIOLOGICAL PSYCHIATRY, 2005, 57 (09) :1068-1072

[9] Decreased serum brain-derived neurotrophic factor levels in major depressed patients [J].

Karege, F ;

Perret, G ;

Bondolfi, G ;

Schwald, M ;

Bertschy, G ;

Aubry, JM .

PSYCHIATRY RESEARCH, 2002, 109 (02) :143-148

[10] Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation? [J].

Kerschensteiner, M ;

Gallmeier, E ;

Behrens, L ;

Leal, VV ;

Misgeld, T ;

Klinkert, WEF ;

Kolbeck, R ;

Hoppe, E ;

Oropeza-Wekerle, RL ;

Bartke, I ;

Stadelmann, C ;

Lassmann, H ;

Wekerle, H ;

Hohlfeld, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) :865-870

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