The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence

被引：1946

作者：

Barker, Holly E. ^{[1
]}

Paget, James T. E. ^{[1
]}

Khan, Aadil A. ^{[1
]}

Harrington, Kevin J. ^{[1
]}

机构：

[1] Inst Canc Res, Targeted Therapy Team, London SW3 6JB, England

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 07期

基金：

英国惠康基金;

关键词：

NEWLY-DIAGNOSED GLIOBLASTOMA; MONOCLONAL-ANTIBODY; 81C6; PANCREATIC-CANCER CELLS; GROWTH-FACTOR-BETA; CD8(+) T-CELLS; MATRIX-METALLOPROTEINASE INHIBITOR; INFLAMMATORY PLAQUE PHENOTYPE; TGF-BETA; IONIZING-RADIATION; HEPATOCELLULAR-CARCINOMA;

D O I：

10.1038/nrc3958

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Radiotherapy plays a central part in curing cancer. For decades, most research on improving treatment outcomes has focused on modulating radiation-induced biological effects on cancer cells. Recently, we have better understood that components within the tumour microenvironment have pivotal roles in determining treatment outcomes. In this Review, we describe vascular, stromal and immunological changes that are induced in the tumour microenvironment by irradiation and discuss how these changes may promote radioresistance and tumour recurrence. We also highlight how this knowledge is guiding the development of new treatment paradigms in which biologically targeted agents will be combined with radiotherapy.

引用

页码：409 / 425

页数：17

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