The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence

被引：1946

作者：

Barker, Holly E. ^{[1
]}

Paget, James T. E. ^{[1
]}

Khan, Aadil A. ^{[1
]}

Harrington, Kevin J. ^{[1
]}

机构：

[1] Inst Canc Res, Targeted Therapy Team, London SW3 6JB, England

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 07期

基金：

英国惠康基金;

关键词：

NEWLY-DIAGNOSED GLIOBLASTOMA; MONOCLONAL-ANTIBODY; 81C6; PANCREATIC-CANCER CELLS; GROWTH-FACTOR-BETA; CD8(+) T-CELLS; MATRIX-METALLOPROTEINASE INHIBITOR; INFLAMMATORY PLAQUE PHENOTYPE; TGF-BETA; IONIZING-RADIATION; HEPATOCELLULAR-CARCINOMA;

D O I：

10.1038/nrc3958

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Radiotherapy plays a central part in curing cancer. For decades, most research on improving treatment outcomes has focused on modulating radiation-induced biological effects on cancer cells. Recently, we have better understood that components within the tumour microenvironment have pivotal roles in determining treatment outcomes. In this Review, we describe vascular, stromal and immunological changes that are induced in the tumour microenvironment by irradiation and discuss how these changes may promote radioresistance and tumour recurrence. We also highlight how this knowledge is guiding the development of new treatment paradigms in which biologically targeted agents will be combined with radiotherapy.

引用

页码：409 / 425

页数：17

共 195 条

[51]

Tyrosine kinase inhibitors for the treatment of fibrotic diseases such as systemic sclerosis: towards molecular targeted therapies [J].

Distler, J. H. W. ;

Distler, O. .

ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 :48-51

[52]

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models [J].

Dredge, K. ;

Hammond, E. ;

Handley, P. ;

Gonda, T. J. ;

Smith, M. T. ;

Vincent, C. ;

Brandt, R. ;

Ferro, V. ;

Bytheway, I. .

BRITISH JOURNAL OF CANCER, 2011, 104 (04) :635-642

[53]

The three Es of cancer immunoediting [J].

Dunn, GP ;

Old, LJ ;

Schreiber, RD .

ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 :329-360

[54]

Durand R E, 1994, In Vivo, V8, P691

[55]

VEGF and the quest for tumour angiogenesis factors [J].

Ferrara, N .

NATURE REVIEWS CANCER, 2002, 2 (10) :795-803

[56]

COMBINATION OF EXTERNAL BEAM RADIOTHERAPY (EBRT) WITH INTRATUMORAL INJECTION OF DENDRITIC CELLS AS NEO-ADJUVANT TREATMENT OF HIGH-RISK SOFT TISSUE SARCOMA PATIENTS [J].

Finkelstein, Steven E. ;

Iclozan, Cristina ;

Bui, Marilyn M. ;

Cotter, Matthew J. ;

Ramakrishnan, Rupal ;

Ahmed, Jamil ;

Noyes, David R. ;

Cheong, David ;

Gonzalez, Ricardo J. ;

Heysek, Randy V. ;

Berman, Claudia ;

Lenox, Brianna C. ;

Janssen, William ;

Zager, Jonathan S. ;

Sondak, Vernon K. ;

Letson, G. Douglas ;

Antonia, Scott J. ;

Gabrilovich, Dmitry I. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 82 (02) :924-932

[57]

Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature [J].

Fokas, Emmanouil ;

Im, Jae Hong ;

Hill, Sally ;

Yameen, Sabira ;

Stratford, Michael ;

Beech, John ;

Hackl, Wolfgang ;

Maira, Sauveur-Michel ;

Bernhard, Eric J. ;

McKenna, W. Gillies ;

Muschel, Ruth J. .

CANCER RESEARCH, 2012, 72 (01) :239-248

[58]

Pilot Trial of Radiation Therapy and GM-CSF in Metastatic Cancer: Abscopal Responses [J].

Formenti, S. ;

Adams, S. ;

Friedman, K. ;

Fenton-Kerimian, M. ;

Donach, M. ;

Goldberg, J. ;

Demaria, S. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 84 (03) :S178-S178

[59]

Tumor response to radiotherapy regulated by endothelial cell apoptosis [J].

Garcia-Barros, M ;

Paris, F ;

Cordon-Cardo, C ;

Lyden, D ;

Rafii, S ;

Haimovitz-Friedman, A ;

Fuks, Z ;

Kolesnick, R .

SCIENCE, 2003, 300 (5622) :1155-1159

[60]

NORMALIZATION OF THE VASCULATURE FOR TREATMENT OF CANCER AND OTHER DISEASES [J].

Goel, Shom ;

Duda, Dan G. ;

Xu, Lei ;

Munn, Lance L. ;

Boucher, Yves ;

Fukumura, Dai ;

Jain, Rakesh K. .

PHYSIOLOGICAL REVIEWS, 2011, 91 (03) :1071-1121

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