Characterization of New Topical Ketoprofen Formulations Prepared by Drug Entrapment in Solid Lipid Matrices

被引:9
作者
Argemi, Anna [1 ]
Domingo, Concepcion [2 ]
Sampaio de Sousa, Ana Raquel [3 ]
Duarte, Catarina M. M. [3 ,4 ]
Garcia-Gonzalez, Carlos A. [2 ]
Saurina, Javier [1 ]
机构
[1] Univ Barcelona, Dept Analyt Chem, E-08028 Barcelona, Spain
[2] CSIC, Inst Ciencia Mat Barcelona, E-08193 Bellaterra, Spain
[3] IBET, P-2781901 Oeiras, Portugal
[4] Inst Tecnol Quim & Biol, P-2780157 Oeiras, Portugal
关键词
ketoprofen determination; HPLC-UV; solid lipid particles; controlled release; microencapsulation; diffusion cell; in-vitro models; kinetics; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; IN-VITRO RELEASE; NANOPARTICLES SLN; SKIN PENETRATION; DELIVERY; ELECTROPHORESIS; PHARMACEUTICALS; PRESERVATIVES; ENCAPSULATION; PARTICLES;
D O I
10.1002/jps.22684
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
This paper describes the evaluation of a new pharmaceutical formulation based on ketoprofen entrapment in a solid lipid particle (SLP) matrix. The drug-SLP samples, which were elaborated using a processing technology based on supercritical CO2, consisted of a model of a controlled-release system for topical applications. Some of the samples contained silanized TiO2 as an additional ingredient to increase the interaction between drug and lipid matrix. The study of the sample features relied on reversed-phase high-performance liquid chromatography with a C-18 column and ultraviolet spectroscopic detection at 266 nm. Characterization assays comprised the determination of the overall amount of ketoprofen in the samples, the assessment of the release-permeation kinetic profiles, and the evaluation of impurities and decomposition products. The release and permeation of encapsulated ketoprofen were assayed at 32 degrees C and pH 6.8 by using a static diffusion cell. Results showed a sustained drug delivery for at least 24 h. Besides, no degradation species were detected throughout the release-permeation processes, which indicated that the stability of the drug in the SLP system was preserved. (C) 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:4783-4789, 2011
引用
收藏
页码:4783 / 4789
页数:7
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