A biological porin engineered into a molecular, nanofluidic diode

被引：68

作者：

Miedema, Henk

Vrouenraets, Maarten

Wierenga, Jenny

Meijberg, Wirn

Robillard, George

Eisenberg, Bob

机构：

[1] Biomade Technol Fdn, NL-9747 AG Groningen, Netherlands

[2] Rush Univ, Med Ctr, Dept Mol Physiol & Biophys, Chicago, IL 60612 USA

来源：

NANO LETTERS | 2007年 / 7卷 / 09期

关键词：

D O I：

10.1021/nl0716808

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We changed the nonrectifying biological porin OmpF into a nanofluidic diode. To that end, we engineered a pore that possesses two spatially separated selectivity filters of opposite charge where either cations or anions accumulate. The observed current inhibition under applied reverse bias voltage reflects, we believe, the creation of a zone depleted of charge carriers, in a sense very similar to what happens at the np junction of a semiconductor device.

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页码：2886 / 2891

页数：6

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