Serum lidocaine concentrations after subcutaneous administration in patients undergoing cardiac catheterization in a pediatric institution

被引：2

作者：

Cassidy, SC

Jones, PR

Cox, S

Walson, PD

Allen, HD

机构：

[1] OHIO STATE UNIV, DEPT PEDIAT, COLUMBUS, OH 43210 USA

[2] CHILDRENS HOSP, DEPT PHARMACOL, COLUMBUS, OH 43205 USA

[3] CHILDRENS HOSP, DEPT TOXICOL, COLUMBUS, OH 43205 USA

来源：

JOURNAL OF PEDIATRICS | 1996年 / 129卷 / 03期

关键词：

D O I：

10.1016/S0022-3476(96)70085-9

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective: We wished to determine serum lidocaine concentrations after subcutaneous injection during cardiac catheterization. Method: Serum lidocaine concentrations were measured in 50 patients during catheterization. Results: Serum concentration was linearly related to dose per kilogram of body weight. Lidocaine concentrations were therapeutic in 38% of patients. Conclusion: Lidocaine dose must be considered when the drug is used for local anesthesia in children.

引用

收藏

页码：464 / 466

页数：3

相关论文

共 12 条

[1] CLINICAL PHARMACOKINETICS OF LIGNOCAINE [J].

BENOWITZ, NL ;

MEISTER, W .

CLINICAL PHARMACOKINETICS, 1978, 3 (03) :177-201

[2] THE INFLUENCE OF A RIGHT-TO-LEFT CARDIAC SHUNT ON LIDOCAINE PHARMACOKINETICS [J].

BOKESCH, PM ;

CASTANEDA, AR ;

ZIEMER, G ;

WILSON, JM .

ANESTHESIOLOGY, 1987, 67 (05) :739-744

[3]

BRIDGES ND, 1995, HEART DIS INFANTS CH, P310

[4]

BUCKLES CS, 1991, J CARDIOVASC ELECTR, V2, P103

[5] SUBCUTANEOUS LIDOCAINE AFFECTS INDUCIBILITY IN PROGRAMMED ELECTROPHYSIOLOGY TESTING IN CHILDREN - A FOLLOW-UP-STUDY [J].

BUCKLES, DS ;

KNICK, B ;

GILLETTE, PC .

AMERICAN HEART JOURNAL, 1992, 124 (05) :1241-1244

[6] COMPLICATIONS OF PEDIATRIC CARDIAC-CATHETERIZATION - A 3-YEAR STUDY [J].

CASSIDY, SC ;

SCHMIDT, KG ;

VANHARE, GF ;

STANGER, P ;

TEITEL, DF .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1992, 19 (06) :1285-1293

[7] LOCAL ANESTHESIA .1. [J].

COVINO, BG .

NEW ENGLAND JOURNAL OF MEDICINE, 1972, 286 (18) :975-+

[8] PHARMACOKINETICS OF LIGNOCAINE IN CHILDREN FOLLOWING CAUDAL ANESTHESIA [J].

ECOFFEY, C ;

DESPARMET, J ;

BERDEAUX, A ;

MAURY, M ;

GIUDICELLI, JF ;

SAINTMAURICE, C .

BRITISH JOURNAL OF ANAESTHESIA, 1984, 56 (12) :1399-1402

[9] PHARMACOKINETICS OF LIGNOCAINE IN CHILDREN AFTER INFILTRATION FOR CLEFT-PALATE SURGERY [J].

MICHAEL, S ;

BARKER, I ;

HENDERSON, P ;

GRIFFITHS, RW ;

REILLY, CS .

BRITISH JOURNAL OF ANAESTHESIA, 1992, 69 (06) :577-579

[10] LIDOCAINE TOXICITY AFTER SUBCUTANEOUS INFILTRATION IN CHILDREN UNDERGOING CARDIAC-CATHETERIZATION [J].

PALMISANO, JM ;

MELIONES, JN ;

CROWLEY, DC ;

MARTIN, JM ;

TRUMAN, KH ;

KRAUZOWICZ, BA ;

ROCCHINI, AP .

AMERICAN JOURNAL OF CARDIOLOGY, 1991, 67 (07) :647-648