In vitro antiplasmodial activity of 4-phenylcoumarins from Exostema mexicanum

被引：37

作者：

Köhler, I

Jenett-Siems, K

Mockenhaupt, FP

Siems, K

Jakupovic, J

González, JC

Hernández, MA

Ibarra, RA

Berendsohn, WG

Bienzle, U

Eich, E

机构：

[1] Free Univ Berlin, Inst Pharm Pharmazeut Biol, D-14195 Berlin, Germany

[2] Humboldt Univ, Fak Med, Charite, Inst Trop Med, D-1040 Berlin, Germany

[3] AnalytiCon AG, Potsdam, Germany

[4] ProBioTec SA de CV, San Salvador, El Salvador

[5] Bot Garten, Berlin, Germany

[6] Bot Museum Berlin Dahlem, Berlin, Germany

来源：

PLANTA MEDICA | 2001年 / 67卷 / 01期

关键词：

D O I：

10.1055/s-2001-10630

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The stem bark of Exostema mexicanum (Rubiaceae) is used in Latin American folk medicine as a quinine substitute for malaria treatment. Bioassay-guided fractionation of lipophilic and hydrophilic extracts from the stem bark and branches yielded two previously undescribed 4-phenylcoumarins: 4:8-dihydroxy-5,7-dimethoxy-4-phenylcoumarin (exomexin A) and 3 :4'-dihydroxy-5,7,8-trimethoxy-4-phenylcoumarin B). Together with five known derivatives the in vitro activities against a chloroquine-sensitive strain (poW) and a chloroquineresistant strain (Dd2) of Plasmodium falciparum have been evaluated. The most lipophilic compound, 4:5,7,8-tetramethoxy-4-phenylcoumarin (O-methylexostemin) revealed the strongest antiplasmodial activity (IC50 values: 3.6 mug/ml [poW], 1.6 mug/ml [Dd2]).

引用

页码：89 / 91

页数：3

共 13 条

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