Intense exercise induces mitochondrial dysfunction in mice brain

被引：39

作者：

Aguiar, Aderbal S., Jr.

Tuon, Talita

Pinho, Cleber A.

Silva, Luciano A.

Andreazza, Ana C.

Kapczinski, Flavio

Quevedo, Joao

Streck, Emilio L.

Pinho, Ricardo A. ^{[1
]}

机构：

[1] Univ Extremo Sul Catarinense, Postgrad Program Hlth Sci, Lab Exercise Physiol & Biochem, BR-88806000 Criciuma, SC, Brazil

[2] Univ Fed Rio Grande do Sul, Dept Biochem, BR-90035003 Porto Alegre, RS, Brazil

[3] Hosp Clin Porto Alegre, Res Ctr, Bipolar Disorders Program, BR-90035003 Porto Alegre, RS, Brazil

[4] Univ Extremo Sul Catarinense, Postgrad Program Hlth Sci, Neurosci Lab, BR-88806000 Criciuma, SC, Brazil

[5] Univ Extremo Sul Catarinense, Postgrad Program Hlth Sci, Lab Expt Physiopathol, BR-88806000 Criciuma, SC, Brazil

来源：

NEUROCHEMICAL RESEARCH | 2008年 / 33卷 / 01期

关键词：

cytochrome c oxidase; citrate synthase; oxidative stress; BDNF; physical exercise; brain;

D O I：

10.1007/s11064-007-9406-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are conflicts between the effects of free radical over-production induced by exercise on neurotrophins and brain oxidative metabolism. The objective of this study was to investigate the effects of intense physical training on brain-derived neurotrophic factor (BDNF) levels, COX activity, and lipoperoxidation levels in mice brain cortex. Twenty-seven adult male CF1 mice were assigned to three groups: control untrained, intermittent treadmill exercise (3 x 15 min/day) and continuous treadmill exercise (45 min/day). Training significantly (P < 0.05) increased citrate synthase activity when compared to untrained control. Blood lactate levels classified the exercise as high intensity. The intermittent training significantly (P < 0.05) reduced in 6.5% the brain cortex COX activity when compared to the control group. BDNF levels significantly (P < 0.05) decreased in both exercise groups. Besides, continuous and intermittent exercise groups significantly (P < 0.05) increased thiobarbituric acid reactive species levels in the brain cortex. In summary, intense exercise promoted brain mitochondrial dysfunction due to decreased BDNF levels in the frontal cortex of mice.

引用

页码：51 / 58

页数：8

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