Presence of synthetic pharmaceuticals as adulterants in slimming phytotherapeutic formulations and their analytical determination

被引：69

作者：

de Carvalho, Leandro M. ^{[1
,2
]}

Martini, Mariele ^{[1
]}

Moreira, Ana Paula L. ^{[1
]}

de Lima, Ana Paula S. ^{[1
]}

Correia, Daniele ^{[1
]}

Falcao, Tatiana ^{[2
]}

Garcia, Solange C. ^{[3
]}

de Bairros, Andre V. ^{[1
]}

do Nascimento, Paulo C. ^{[1
]}

Bohrer, Denise ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, BR-97110970 Santa Maria, RS, Brazil

[2] Univ Fed Santa Maria, PPGCF, Ctr Ciencias Saude, BR-97110970 Santa Maria, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Dept Anal Clin & Toxicol, Porto Alegre, RS, Brazil

来源：

FORENSIC SCIENCE INTERNATIONAL | 2011年 / 204卷 / 1-3期

关键词：

Adulterants; Slimming phytotherapeutic formulations; Analytical methods; PERFORMANCE LIQUID-CHROMATOGRAPHY; CAPILLARY-ELECTROPHORESIS; DIETARY-SUPPLEMENTS; GAS-CHROMATOGRAPHY; HERBAL MEDICINES; AMFEPRAMONE HYDROCHLORIDE; DIAZEPAM; WEIGHT; DRUG; BENZODIAZEPINES;

D O I：

10.1016/j.forsciint.2010.04.045

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

030101 [法学理论]; 030111 [法律史学]; 100218 [急诊医学];

摘要：

Obesity that is associated with a high consumption of slimming substances is considered a public health problem around the world. In this context, the increasing consumption of phytotherapeutic formulations as alternative obesity treatments has revealed the presence of synthetic pharmaceuticals as adulterants. The illegally added adulterants are frequently anorexic, anxiolytic, and antidepressant pharmaceuticals. This review aims to describe the analytical methodologies utilized for the determination of adulterants in slimming phytotherapeutic formulations. Furthermore, this review describes some important adulteration cases, which occurred mainly in Europe, Asia, Brazil, and the USA. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：6 / 12

页数：7

共 52 条

[1]

Public awareness of the abuse of herbs and drugs to decrease body weight: A novel national survey in Jordan [J].

Al-Safi S.A. ;

Ayoub N.M. ;

Ayoub A.M. ;

Al-Momany E. ;

Al-Doghim I. ;

Al-Balas M. ;

Alkofahi A.S. ;

Aboul-Enein F.H. ;

Aboul-Enein B.H. .

Journal of Public Health, 2008, 16 (3) :205-213

[2]

High-performance liquid chromatographic determination of amfepramone hydrochloride, mazindol, and diazepam in tablets [J].

Almeida, AE ;

Ribeiro, ML .

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 1999, 22 (11) :1759-1769

[3]

Determination of amfepramone hydrochloride, fenproporex, and diazepam in so-called "natural" capsules used in the treatment of obesity [J].

Almeida, AE ;

Ribeiro, ML ;

Polese, L .

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2000, 23 (07) :1109-1118

[4]

Capillary electrophoresis for forensic drug analysis: A review [J].

Anastos, N ;

Barnett, NW ;

Lewis, SW .

TALANTA, 2005, 67 (02) :269-279

[5]

AURICCHIO M T, 1991, Revista do Instituto Adolfo Lutz, V51, P105

[6]

Azeredo F.S., 2005, INFARMA, V17, P86

[7]

Determination of Diazepam and associated compounds in pharmaceutical preparations [J].

Berzas, JJ ;

Castañeda, G ;

Pinilla, MJ .

FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY, 1999, 364 (06) :570-575

[8]

Application of LC-ESI-MS-MS for detection of synthetic adulterants in herbal remedies [J].

Bogusz, MJ ;

Hassan, H ;

Ai-Enazi, E ;

Ibrahim, Z ;

Al-Tufail, M .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2006, 41 (02) :554-564

[9]

Chaves Maria Auxiliadora, 1994, Revista do Instituto Adolfo Lutz, V54, P36

[10]

Analysis of potential adulteration in herbal medicines and dietary supplements for the weight control by capillary electrophoresis [J].

Cianchino, Valeria ;

Acosta, Gimena ;

Ortega, Claudia ;

Martinez, Luis D. ;

Gomez, Maria R. .

FOOD CHEMISTRY, 2008, 108 (03) :1075-1081

← 1 2 3 4 5 6 →