Direct preparation of peptide thioesters using an Fmoc solid-phase method

被引：161

作者：

Li, XQ ^{[1
]}

Kawakami, T ^{[1
]}

Aimoto, S ^{[1
]}

机构：

[1] Osaka Univ, Inst Prot Res, Osaka 5650871, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 47期

关键词：

peptides and polypeptides; thioesters; deblocking; solid-phase synthesis;

D O I：

10.1016/S0040-4039(98)01868-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aiming at the direct preparation of peptide thioesters by an Fmoc solid-phase method, we searched a new deblocking reagent, which efficiently removed Fmoc groups while keeping the thioester intact. The deblocking reagent, which contains 1-methylpyrrolidine, hexamethyleneimine and HOBt in a one to one mixture of NMP and DMSO, realized the preparation of peptide thioesters by an Fmoc solid-phase method in a yield equivalent to that obtained by a Boc solid-phase method. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8669 / 8672

页数：4

共 13 条

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