Condensation of Cys(Acm)-containing peptide segments with silver chloride as an activator of peptide thioesters

被引：14

作者：

Kawakami, T ^{[1
]}

Aimoto, S ^{[1
]}

机构：

[1] OSAKA UNIV, INST PROT RES, SUITA, OSAKA 565, JAPAN

来源：

CHEMISTRY LETTERS | 1997年 / 11期

关键词：

D O I：

10.1246/cl.1997.1157

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The undesirable removal of an acetamidomethyl (Acm) group in a Cys(Acm) residue is suppressed during the segment condensation of peptides, when silver chloride is used as an activator of the thioester moiety in a partially protected peptide thioester. The rate of segment condensation is sufficiently high enough for its application to practical peptide synthesis.

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页码：1157 / 1158

页数：2

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