Enantioselective organocatalytic aldol reaction of unactivated ketones with isatins

被引：73

作者：

Allu, Suresh ^{[1
]}

Molleti, Nagaraju ^{[2
]}

Panem, Ramachandrarao ^{[1
]}

Singh, Vinod K. ^{[1
,2
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

[2] Indian Inst Sci Educ & Res, Dept Chem, Bhopal 462023, MP, India

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 32期

关键词：

Organocatalysis; Thiourea; Isatin; Enamine mechanism; 3-Alkyl-3-hydroxyindolin-2-ones; CINCHONA ALKALOID DERIVATIVES; ASYMMETRIC ALDOL; STEREOSELECTIVE-SYNTHESIS; MICHAEL ADDITION; PROLINE; ACETALDEHYDE; ACID; CONDENSATION; ENOLIZATION; ALDEHYDES;

D O I：

10.1016/j.tetlet.2011.05.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective organocatalytic direct aldol reaction of unactivated ketones with various isatin derivatives was developed using cinchonine based urea ligand employing a noncovalent catalysis mechanism. Using this protocol we can access functionalized 3-alkyl-3-hydroxyindolin-2-ones in high yields with good to excellent enantioselectivities. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：4080 / 4083

页数：4

共 52 条

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