Homogeneous synthesis and characterization of chitosan ethers prepared in aqueous alkali/urea solutions

被引：64

作者：

Cao, Jinfeng

You, Jun

Zhang, Lina

Zhou, Jinping ^{[1
]}

机构：

[1] Wuhan Univ, Minist Educ, Dept Chem, Wuhan 430072, Hubei, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2018年 / 185卷

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

Chitosan ethers; Aqueous alkali/urea solution; Homogeneous synthesis; Reactivity; Degree of substitution; CARBOXYMETHYL CHITOSAN; METHYLATED CHITOSAN; BIOMEDICAL APPLICATIONS; HYDROXYPROPYL CHITOSAN; ANTIBACTERIAL ACTIVITY; HYDROGELS; DERIVATIVES; CELLULOSE; CHITIN; QUATERNIZATION;

D O I：

10.1016/j.carbpol.2018.01.010

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

The etherification of chitosan dissolved in aqueous LiOH/KOH/urea solutions was conducted for the first time. The structure and solution properties of the chitosan ethers were characterized using FT-IR, NMR, SEC-LLS, elemental analysis, and zeta-potential measurement. Chitosan ethers with different degrees of substitution (DSs) were obtained by adjusting the molar ratio of the etherifying agent to N-acetylglucosamine unit (AGU) of chitosan. The total DS for methyl chitosan (MCh) increased from 1.17 to 2.25, and trimethyl chitosan (TMCh) was obtained with DSN-trimethyl as high as 0.48. The total DS for carboxymethyl chitosan (CMCh) was in the range 0.75-1.45. Both N-substitution and O-substitution were observed, and the eOH groups at C-6 displayed relative higher reactivity than the -OH groups at C-3. In comparison with the traditional methods and solvents, aqueous alkali/urea solutions proved to be a stable and more homogeneous medium for preparing chitosan ethers with higher DS through a one-step reaction.

引用

页码：138 / 144

页数：7

共 41 条

[21]

Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications [J].