Determination of degradation products of sumatriptan succinate using LC-MS and LC-MS-MS

被引：30

作者：

Xu, XH ^{[1
]}

Bartlett, MG ^{[1
]}

Stewart, JT ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2001年 / 26卷 / 03期

关键词：

sumatriptan succinate; LC-MS; LC-MS-MS; stability; degradation pathway; degradant identification;

D O I：

10.1016/S0731-7085(01)00409-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Acid, base, heat, oxidation and UV irradiation stress methods were applied to study the stability of the bulk drug form of sumatriptan succinate. Liquid chromatography coupled with mass spectrometry (LC-MS and LC-MS-MS) was used to analyze the degraded samples and tentative structural identifications were assigned based upon known reactivity of the drug, molecular weight measurements and MS-MS fragmentation patterns. Sumatriptan succinate was found to be stable to exposure of acid, base, oxidation and UV irradiation at ambient conditions, but was found to degrade under acidic, basic and oxidative conditions when heated to 90 degreesC. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：367 / 377

页数：11

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