Evidence that GABA augmentation of norepinephrine release is mediated by interneurons

被引：16

作者：

Fiber, JM ^{[1
]}

Etgen, AM ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA

来源：

BRAIN RESEARCH | 1998年 / 790卷 / 1-2期

关键词：

preoptic area; hypothalamus; frontal cortex; brain slices; synaptosome; NMDA;

D O I：

10.1016/S0006-8993(98)00101-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GABA(A) receptor activation augments stimulated release of H-3-norepinephrine (NE) in brain slices from female rats. This effect is not blocked by acetazolamide or MK-801, indicating that permeability of the GABA(A) chloride channel to bicarbonate ions and NMDA receptor activation do not mediate GABA-induced NE release. Furthermore, GABA augments H-3-NE release from slices, but not from isolated nerve terminals (synaptosomes), indicating that interneurons mediate GABA effects on H-3-NE release. (C) 1998 Elsevier Science B.V.

引用

页码：329 / 333

页数：5

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