IL-17 and IL-22: siblings, not twins

被引：204

作者：

Eyerich, Stefanie ^{[1
,2
,3
]}

Eyerich, Kilian ^{[2
,3
,4
]}

Cavani, Andrea ^{[4
]}

Schmidt-Weber, Carsten ^{[1
]}

机构：

[1] Imperial Coll London, Natl Heart & Lung Inst, Dept Allergy & Clin Immunol, London, England

[2] Tech Univ Munich, Div Environm Dermatol & Allergy, Helmholtz Ctr Munich Tech Univ Munich, Munich, Germany

[3] Tech Univ Munich, ZAUM Ctr Allergy & Environm, Munich, Germany

[4] IRCCS, Immunol Lab, Ist Dermopat Immacolata, Rome, Italy

来源：

TRENDS IN IMMUNOLOGY | 2010年 / 31卷 / 09期

关键词：

COLLAGEN-INDUCED ARTHRITIS; GROWTH-FACTOR-BETA; T-HELPER-CELLS; ARYL-HYDROCARBON RECEPTOR; MUCOSAL HOST-DEFENSE; TH17; CELLS; GENE-EXPRESSION; INTERLEUKIN; 22; CUTTING EDGE; T-H-17;

D O I：

10.1016/j.it.2010.06.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper (Th) cell subsets secrete cytokines that regulate other immune cells. Interleukin (IL)-17 and IL-22 belong to a new class of cytokines with predominant effects on epithelial cells. Thus, these cytokines are key molecules in several disease processes. IL-17 and IL-22 are released by leukocytes such as Th and natural killer cell populations. Both IL-17 and IL-22 induce an innate immune response in epithelial cells, but their functional spectra are generally distinct. IL-17 induces an inflammatory tissue response and is involved in the pathogenesis of several autoimmune diseases, whereas IL-22 is protective/regenerative. This review juxtaposes IL-17 and IL-22 and describes overlaps and differences regarding their cellular sources, biochemical structure, signaling cascades in target cells, and function.

引用

页码：354 / 361

页数：8

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