Immune regulation by Foxo transcription factors

被引：43

作者：

Peng, Stanford L. ^{[1
]}

机构：

[1] Transplantat Res, Palo Alto, CA 94304 USA

来源：

AUTOIMMUNITY | 2007年 / 40卷 / 06期

关键词：

transcription factors; autoimmunity; T cells; B cells; arthritis; lupus;

D O I：

10.1080/08916930701464913

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Foxo subfamily of forkhead (Fox) transcription factors are mammalian homologues of the Caenorhabditis elegans DAF-16 longevity gene, and play key roles in cellular and organism survival, death, proliferation and metabolism. A growing body of evidence indicates that Foxo proteins furthermore play critical roles in immune cell homeostasis, modulating inflammation in some disease states such as inflammatory arthritis and systemic lupus erythematosus (SLE), via fundamental roles in T cells, B cells, neurophils and other myeloid lineages. This review summarizes current knowledge of the Foxo family members in general and in immunity, including their potential use as therapeutic targets.

引用

收藏

页码：462 / 469

页数：8

相关论文

共 71 条

[1] FoxOs at the crossroads of cellular metabolism, differentiation, and transformation [J].

Accili, D ;

Arden, KC .

CELL, 2004, 117 (04) :421-426

[2] Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1 [J].

Asada, Sachie ;

Daitoku, Hiroaki ;

Matsuzaki, Hitomi ;

Saito, Tomoko ;

Sudo, Tatsuhiko ;

Mukai, Hidehito ;

Iwashita, Shintaro ;

Kako, Koichiro ;

Kishi, Tsutomu ;

Kasuya, Yoshitoshi ;

Fukamizu, Akiyoshi .

CELLULAR SIGNALLING, 2007, 19 (03) :519-527

[3] GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis [J].

Asselin-Labat, ML ;

David, M ;

Biola-Vidamment, A ;

Lecoeuche, D ;

Zennaro, MC ;

Bertoglio, J ;

Pallardy, M .

BLOOD, 2004, 104 (01) :215-223

[4] Mechanisms of disease: transcription factors in inflammatory arthritis [J].

Aud, Dee ;

Peng, Stanford L. .

NATURE CLINICAL PRACTICE RHEUMATOLOGY, 2006, 2 (08) :434-442

[5] FOXO3a induces differentiation of Bcr-Abl- transformed cells through transcriptional down-regulation of Id1 [J].

Birkenkamp, Kim U. ;

Essafi, Abdelkader ;

van der Vos, Kristan E. ;

da Costa, Marco ;

Hui, Rosaline C. -Y ;

Holstege, Frank ;

Koenderman, Leo ;

Lam, Eric W. -F. ;

Coffer, Paul J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (04) :2211-2220

[6] Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a) [J].

Brunet, A ;

Park, J ;

Tran, H ;

Hu, LS ;

Hemmings, BA ;

Greenberg, ME .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (03) :952-965

[7] Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor [J].

Brunet, A ;

Bonni, A ;

Zigmond, MJ ;

Lin, MZ ;

Juo, P ;

Hu, LS ;

Anderson, MJ ;

Arden, KC ;

Blenis, J ;

Greenberg, ME .

CELL, 1999, 96 (06) :857-868

[8] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [J].

Brunet, A ;

Sweeney, LB ;

Sturgill, JF ;

Chua, KF ;

Greer, PL ;

Lin, YX ;

Tran, H ;

Ross, SE ;

Mostoslavsky, R ;

Cohen, HY ;

Hu, LS ;

Cheng, HL ;

Jedrychowski, MP ;

Gygi, SP ;

Sinclair, DA ;

Alt, FW ;

Greenberg, ME .

SCIENCE, 2004, 303 (5666) :2011-2015

[9] Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a [J].

Castrillon, DH ;

Miao, LL ;

Kollipara, R ;

Horner, JW ;

DePinho, RA .

SCIENCE, 2003, 301 (5630) :215-218

[10] Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression [J].

Charvet, Celine ;

Canonigo, Ann Janette ;

Becart, Stephane ;

Maurer, Ulrich ;

Miletic, Ana V. ;

Swat, Wojciech ;

Deckert, Marcel ;

Altman, Amnon .

JOURNAL OF IMMUNOLOGY, 2006, 177 (08) :5024-5031

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