Immune regulation by Foxo transcription factors

被引：43

作者：

Peng, Stanford L. ^{[1
]}

机构：

[1] Transplantat Res, Palo Alto, CA 94304 USA

来源：

AUTOIMMUNITY | 2007年 / 40卷 / 06期

关键词：

transcription factors; autoimmunity; T cells; B cells; arthritis; lupus;

D O I：

10.1080/08916930701464913

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Foxo subfamily of forkhead (Fox) transcription factors are mammalian homologues of the Caenorhabditis elegans DAF-16 longevity gene, and play key roles in cellular and organism survival, death, proliferation and metabolism. A growing body of evidence indicates that Foxo proteins furthermore play critical roles in immune cell homeostasis, modulating inflammation in some disease states such as inflammatory arthritis and systemic lupus erythematosus (SLE), via fundamental roles in T cells, B cells, neurophils and other myeloid lineages. This review summarizes current knowledge of the Foxo family members in general and in immunity, including their potential use as therapeutic targets.

引用

收藏

页码：462 / 469

页数：8

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