ALZHEIMER DISEASE Caspases first

被引：26

作者：

Avila, Jesus ^{[1
]}

机构：

[1] Ctr Biol Mol Severo Ochoa CSIC UAM, Madrid 28049, Spain

来源：

NATURE REVIEWS NEUROLOGY | 2010年 / 6卷 / 11期

关键词：

NEUROFIBRILLARY TANGLES; MOUSE MODEL; TAU; CLEAVAGE; TAUOPATHY; NEURONS; LINKING;

D O I：

10.1038/nrneurol.2010.157

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

A direct role for large tau aggregates in neurodegeneration has been challenged by new data indicating that, in relation to degeneration of neurons, caspase activation precedes tangle formation. The findings suggest that any toxic tau moiety related to neurodegeneration is likely to be soluble rather than aggregated.

引用

页码：587 / 588

页数：2

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