Integrative physiology of the aging bone: insights from animal and cellular models

被引：18

作者：

Syed, Farhan A. ^{[1
]}

Hoey, Kelley A. ^{[2
]}

机构：

[1] Abbot Biores Ctr, Worcester, MA 01605 USA

[2] Mayo Clin, Rochester, MN USA

来源：

MOLECULAR AND INTEGRATIVE PHYSIOLOGY OF THE MUSCULOSKELETAL SYSTEM | 2010年 / 1211卷

关键词：

bone loss; aging; animal models; MESENCHYMAL STEM-CELLS; AGE-RELATED-CHANGES; NONHUMAN PRIMATE MODELS; OSTEOBLAST DIFFERENTIATION; TRANSCRIPTION FACTOR; PPAR-GAMMA; ADIPOCYTE DIFFERENTIATION; OXIDATIVE STRESS; MINERAL DENSITY; TRABECULAR BONE;

D O I：

10.1111/j.1749-6632.2010.05813.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ape-related bone loss is a common worldwide phenomenon in the aging population, placing them at an increased risk of fractures. Fortunately, basic and translational studies have been pivotal in providing us with a mechanistic understanding of the cellular and molecular pathophysiology of this condition. This review focuses on the current concepts and paradigms of age-related bone loss and how various animal and cellular models have broadened our understanding in this fascinating but complex area. Changes in hormonal, neuronal, and biochemical cues with age and their effect on bone have been discussed. This review also outlines recent studies on the relationship between bone and fat in the marrow, as well as the fate of the marrow mesenchymal stromal cell population, which can give rise to either bone-forming osteoblasts or fat-forming adipocytic cells as a function of age.

引用

页码：95 / 106

页数：12

共 113 条

[91] Impaired marrow osteogenesis is associated with reduced endocortical bone formation but does not impair periosteal bone formation in long bones of SAMP6 mice [J].