Tramadol and several anticonvulsants synergize in attenuating nerve injury-induced allodynia

被引：33

作者：

Codd, Ellen E. ^{[1
]}

Martinez, Rebecca P. ^{[1
]}

Molino, Lory ^{[1
]}

Rogers, Kathryn E. ^{[1
]}

Stone, Dennis J. ^{[1
]}

Tallarida, Ronald J. ^{[2
]}

机构：

[1] Johnson & Johnson Pharamaceut Res & Dev, Res & Early Dev, Spring House, PA 19477 USA

[2] Temple Univ, Sch Med, Philadelphia, PA USA

来源：

PAIN | 2008年 / 134卷 / 03期

关键词：

tramadol; topiramate; neuropathic pain; spinal nerve ligation; antiallodynic; analgesic synergy;

D O I：

10.1016/j.pain.2007.04.019

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Neuropathic pain results from injury or dysfunction of the central or peripheral nervous system. The treatment of neuropathic pain is challenging, in part because of its multiple etiologies. The present study explores combinations of the analgesic tramadol and each of four anticonvulsants in the treatment of surgically induced (ligation of the L5 spinal nerve) allodynia in rats. Each of the five drugs studied exhibited a dose-dependent antiallodynic effect. When studied in combination, tramadol and each of two of the anticonvulsants (topiramate and RWJ-333369) interacted synergistically at all three ratios studied, whereas tramadol and each of the other two anticonvulsants (gabapentin and lamotrigine) exhibited a synergistic antiallodynic effect at only one of three ratios investigated. In addition, tramadol and topiramate were found to interact synergistically in a nociceptive pain model, the mouse hot-plate test. These studies suggest the benefit of using combinations of analgesics and anticonvulsants in the relief of neuropathic pain. (c) 2007 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

引用

页码：254 / 262

页数：9

共 23 条

[1]

BERDE CH, 1997, IASP NEWSLETTER JAN, P3

[2] Antiepileptics and the treatment of neuropathic pain: Evidence from animal models [J].

Blackburn-Munro, G ;

Erichsen, HK .

CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (23) :2961-2976

[3] QUANTITATIVE ASSESSMENT OF TACTILE ALLODYNIA IN THE RAT PAW [J].

CHAPLAN, SR ;

BACH, FW ;

POGREL, JW ;

CHUNG, JM ;

YAKSH, TL .

JOURNAL OF NEUROSCIENCE METHODS, 1994, 53 (01) :55-63

[4]

CODD EE, 1995, J PHARMACOL EXP THER, V274, P1263

[5] INTERACTION OF THE CENTRAL ANALGESIC, TRAMADOL, WITH THE UPTAKE AND RELEASE OF 5-HYDROXYTRYPTAMINE IN THE RAT-BRAIN INVITRO [J].

DRIESSEN, B ;

REIMANN, W .

BRITISH JOURNAL OF PHARMACOLOGY, 1992, 105 (01) :147-151

[6]

DUHMKE RM, 2004, TRAMADOL NEUROPATHIC

[7] Advances in neuropathic pain - Diagnosis, mechanisms, and treatment recommendations [J].

Dworkin, RH ;

Backonja, M ;

Rowbotham, MC ;

Allen, RR ;

Argoff, CR ;

Bennett, GJ ;

Bushnell, MC ;

Farrar, JT ;

Galer, BS ;

Haythornthwaite, JA ;

Hewitt, DJ ;

Loeser, JD ;

Max, MB ;

Saltarelli, M ;

Schmader, KE ;

Stein, C ;

Thompson, D ;

Turk, DC ;

Wallace, MS ;

Watkins, LR ;

Weinstein, SM .

ARCHIVES OF NEUROLOGY, 2003, 60 (11) :1524-1534

[8]

EDDY NB, 1953, J PHARMACOL EXP THER, V107, P385

[9]

FIELDS HL, 1999, TXB PAIN, P1523

[10]

FOLEY KM, 2006, CANC PAIN RELEASE, P19

← 1 2 3 →