Immunosenescence and anti-immunosenescence therapies: The case of probiotics

被引：34

作者：

Candore, Giuseppina ^{[1
]}

Balistreri, Carmela Rita ^{[1
]}

Colonna-Romano, Giuseppina ^{[1
]}

Grimaldi, Maria Paola ^{[1
]}

Lio, Domenico ^{[1
]}

Listi, Florinda ^{[1
]}

Scola, Letizia ^{[1
]}

Vasto, Sonya ^{[1
]}

Caruso, Calogero ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Biopatol & Metodol Biomed, Grp Studio Sull Immunosenescenza, I-90134 Palermo, Italy

来源：

REJUVENATION RESEARCH | 2008年 / 11卷 / 02期

关键词：

D O I：

10.1089/rej.2008.0662

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is a complex process that negatively impacts the development of the immune system and its ability to function. Progressive changes in the T and B cell systems over the life span have a major impact on the capacity to respond to immune challenge. These cumulative age-associated changes in immune competence are termed immunosenescence. This process is mostly characterized by: (1) shrinkage of the T cell repertoire and accumulation of oligoclonal expansions of memory/effector cells directed toward ubiquitary infectious agents; (2) involution of the thymus and the exhaustion of naive T cells; and (3) chronic inflammatory status. Here we discuss possible strategies to counteract these main aspects of immunosenescence, in particular the role of the normalization of intestinal microflora by probiotics. A better understanding of immunosenescence and the development of new strategies to counteract it are essential for improving the quality of life of the elderly population.

引用

页码：425 / 432

页数：8

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