Postnatal development of dopamine D1-like receptors in rat cortical and striatolimbic brain regions:: An autoradiographic study

被引:129
作者
Tarazi, FI
Tomasini, EC
Baldessarini, RJ
机构
[1] Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Colsolidated Dept Psychiat, Boston, MA 02115 USA
[3] Massachusetts Gen Hosp, McLean Div, Mailman Res Ctr, Belmont, MA USA
关键词
autoradiography; caudate-putamen; cerebral cortex; dopamine D-1-like receptor; entorhinal cortex; frontal cortex; hippocampus; nucleus accumbens septi; postnatal development;
D O I
10.1159/000017365
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Postnatal development of dopamine D-1-like (D-1/D-5) receptors in rat caudate-putamen (CPu), nucleus accumbens (NAc), hippocampus, frontal and entorhinal cerebral cortex was assessed between postnatal days (PD) 7-60 by in vitro receptor autoradiography. Density of [H-3]SCH-23390 binding to D-1-like receptors increased from PD-7 to a peak at PD-28 in CPu (11-fold) and NAc (23-fold), then declined by 20-40% in both regions over PD-35-60, to adult levels. In hippocampus, frontal and entorhinal cortex, D-1-like receptors increased by lesser amounts (3- to 4-fold) from PD-7 to stable, maximal adult levels at PD-60. Evidently, excess D-1-like receptors were eliminated during maturation of CPu and NAc, but not in the other forebrain regions. Postnatal D-1-like receptor development in rat forebrain paralleled that of D2- and D-4-like receptors in the same regions.
引用
收藏
页码:43 / 49
页数:7
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