Recycling to remodel: evolution of dosage-compensation complexes

被引：40

作者：

Pannuti, A

Lucchesi, JC

机构：

[1] Emory Univ, Dept Biol, Atlanta, GA 30322 USA

[2] Emory Univ, Grad Program Genet & Mol Biol, Atlanta, GA 30322 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0959-437X(00)00136-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In diploid species where sex determination involves heteromorphic sex chromosomes, a mechanism has evolved to compensate for gene-dosage differences in sex-linked genes between the sexes. This regulatory mechanism, which is based on chromatin remodeling, is the function of complexes that include components themselves involved in other cellular functions or with homologs that are involved in such functions. Directing these complexes to the correct chromosome in the appropriate sex relies on pioneer or novel components as well as on the presence of sequence-dependent target sites.

引用

页码：644 / 650

页数：7

共 60 条

[1] Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila [J].