共 33 条
Vagotomy in young obese hyperglycemic mice:: effects on syndrome development and islet proliferation
被引:58
作者:
Edvell, A
[1
]
Lindström, P
[1
]
机构:
[1] Umea Univ, Dept Histol & Cell Biol, S-90187 Umea, Sweden
来源:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
|
1998年
/
274卷
/
06期
关键词:
pancreatic islets;
D O I:
10.1152/ajpendo.1998.274.6.E1034
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Obese hyperglycemic mice have large pancreatic islets and high levels of serum insulin and blood glucose. Vagotomy was performed on 3-wk-old animals to investigate the role of gut cholinergic innervation in young Ume (a) over circle ob/ob mice. After vagotomy, obesity and hyperglycemia are dissociated. Weight increase in obese vagotomized mice was lower than in sham-operated controls during the Ist wk postoperatively but not thereafter Blood glucose was lower up to 5 mo after vagotomy, but vagotomized mice showed reduced glucose tolerance. Islet cell proliferation rate was reduced 2 and 3 wk but not 5 mo after vagotomy. After 5 mo, islet volume was smaller in vagotomized mice. Serum insulin levels were the same in vagotomized animals as in sham-operated controls. The effects of reduced cholinergic innervation are probably caused both by direct effects of denervation and by lowered metabolic demand.
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页码:E1034 / E1039
页数:6
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