Vagotomy in young obese hyperglycemic mice:: effects on syndrome development and islet proliferation

被引:58
作者
Edvell, A [1 ]
Lindström, P [1 ]
机构
[1] Umea Univ, Dept Histol & Cell Biol, S-90187 Umea, Sweden
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 1998年 / 274卷 / 06期
关键词
pancreatic islets;
D O I
10.1152/ajpendo.1998.274.6.E1034
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obese hyperglycemic mice have large pancreatic islets and high levels of serum insulin and blood glucose. Vagotomy was performed on 3-wk-old animals to investigate the role of gut cholinergic innervation in young Ume (a) over circle ob/ob mice. After vagotomy, obesity and hyperglycemia are dissociated. Weight increase in obese vagotomized mice was lower than in sham-operated controls during the Ist wk postoperatively but not thereafter Blood glucose was lower up to 5 mo after vagotomy, but vagotomized mice showed reduced glucose tolerance. Islet cell proliferation rate was reduced 2 and 3 wk but not 5 mo after vagotomy. After 5 mo, islet volume was smaller in vagotomized mice. Serum insulin levels were the same in vagotomized animals as in sham-operated controls. The effects of reduced cholinergic innervation are probably caused both by direct effects of denervation and by lowered metabolic demand.
引用
收藏
页码:E1034 / E1039
页数:6
相关论文
共 33 条
[31]   MILK INTAKES OF GENETICALLY-OBESE (OB/OB) AND LEAN MOUSE PUPS DIFFER WITH ENHANCED MILK SUPPLY [J].
WILSON, LM ;
STEWART, ML ;
MCANANAMA, EP .
PHYSIOLOGY & BEHAVIOR, 1989, 46 (05) :823-827
[32]   NEURAL CONTROL OF ENDOCRINE PANCREAS [J].
WOODS, SC ;
PORTE, D .
PHYSIOLOGICAL REVIEWS, 1974, 54 (03) :596-619
[33]   POSITIONAL CLONING OF THE MOUSE OBESE GENE AND ITS HUMAN HOMOLOG [J].
ZHANG, YY ;
PROENCA, R ;
MAFFEI, M ;
BARONE, M ;
LEOPOLD, L ;
FRIEDMAN, JM .
NATURE, 1994, 372 (6505) :425-432