RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection

被引：39

作者：

Cirioni, Oscar

Ghiselli, Roberto

Minardi, Daniele

Orlando, Fiorenza

Mocchegiani, Federico

Silvestri, Carmela

Muzzonigro, Giovanni

Saba, Vittorio

Scalise, Giorgio

Balaban, Naomi

Giacometti, Andrea

机构：

[1] Polytech Univ Marche Reg, Inst Infect Dis & Publ Hlth, AO Osped Riuniti, Ancona, Italy

[2] Polytech Univ Marche Reg, IRRCS, INRCA, Dept Gen Surg, Ancona, Italy

[3] Polytech Univ Marche Reg, AO Osped Riuniti, Inst Maternal & Childrens Sci Urol, Ancona, Italy

[4] INRCA IRRCS, Res Dept, Expt Anim Models Aging Units, Ancona, Italy

[5] Tufts Univ, Cummings Sch Vet Med, Dept Biomed Sci, North Grafton, MA 01536 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 12期

关键词：

D O I：

10.1128/AAC.00808-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections.

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收藏

页码：4518 / 4520

页数：3

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