Trading translation with RNA-binding proteins

被引:46
作者
Abaza, Irina [1 ]
Gebauer, Fatima [1 ]
机构
[1] CRG, Gene Regulat Programme, Barcelona 08003, Spain
关键词
translation; RNA-binding proteins; hnRNP K; SXL; Maskin; cup; IRP; GAIT; CPEB; Smaug;
D O I
10.1261/rna.848208
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
RNA-binding proteins regulate every aspect of RNA metabolism, including pre-mRNA splicing, mRNA trafficking, stability, and translation. This review summarizes the available information on molecular mechanisms of translational repression by RNA-binding proteins. By using a specific set of well-defined examples, we also describe how regulation can be reversed.
引用
收藏
页码:404 / 409
页数:6
相关论文
共 61 条
[1]   Drosophila UNR is required for translational repression of male-specific lethal 2 mRNA during regulation of X-chromosome dosage compensation [J].
Abaza, I ;
Coll, O ;
Patalano, S ;
Gebauer, F .
GENES & DEVELOPMENT, 2006, 20 (03) :380-389
[2]   Deciphering the cross talk between hnRNP K and c-Src: the c-Src activation domain in hnRNP K is distinct from a second interaction site [J].
Adolph, Doerte ;
Flach, Nadine ;
Mueller, Katharina ;
Ostareck, Dirk H. ;
Ostareck-Lederer, Antje .
MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (05) :1758-1770
[3]  
[Anonymous], 2007, SCI SINGAL, DOI DOI 10.1126/STKE.3672007RE1
[4]   Differential phosphorylation controls maskin association with eukaryotic translation initiation factor 4E and localization on the mitotic apparatus [J].
Barnard, DC ;
Cao, QP ;
Richter, JD .
MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (17) :7605-7615
[5]   Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation [J].
Barnard, DC ;
Ryan, K ;
Manley, JL ;
Richter, JD .
CELL, 2004, 119 (05) :641-651
[6]   A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila [J].
Beckmann, K ;
Grskovic, M ;
Gebauer, F ;
Hentze, MW .
CELL, 2005, 122 (04) :529-540
[7]   Dissolution of the maskin-eIF4E complex by cytoplasmic polyadenylation and poly(A)-binding protein controls cyclin B1 mRNA translation and oocyte maturation [J].
Cao, QP ;
Richter, JD .
EMBO JOURNAL, 2002, 21 (14) :3852-3862
[8]   CDK1 and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression [J].
Cao, Quiping ;
Kim, Jong Heon ;
Richter, Joel D. .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (12) :1128-1134
[9]   Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles [J].
Chekulaeva, M ;
Hentze, MW ;
Ephrussi, A .
CELL, 2006, 124 (03) :521-533
[10]   Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos [J].
Cho, Park F. ;
Gamberi, Chiara ;
Cho-Park, Yoon Andrew ;
Cho-Park, Ian B. ;
Lasko, Paul ;
Sonenberg, Nahum .
CURRENT BIOLOGY, 2006, 16 (20) :2035-2041