Asymmetric hydrogenation of enamides with catalysts containing chiral thiourea ligands

被引：38

作者：

Tommasino, ML ^{[1
]}

Casalta, M ^{[1
]}

Breuzard, JAJ ^{[1
]}

Lemaire, M ^{[1
]}

机构：

[1] CNRS, Lab Catalyse & Synthese Organ, UMR 5622, CPE, F-69622 Villeurbanne, France

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 24期

关键词：

D O I：

10.1016/S0957-4166(00)00489-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The asymmetric reduction of enamides with molecular, hydrogen and catalytic amounts of rhodium, iridium or ruthenium complexes containing chiral N,S-ligands is reported. Various enantiomerically pure mono- and dithioureas were examined. The C-2-symmetry of the dithiourea ligands seems essential to the enantioselectivity achieved. Ee values of up to 70% were observed. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4835 / 4841

页数：7

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