Cholesteryl ester transfer protein inhibitors

被引：100

作者：

Shinkai, H ^{[1
]}

机构：

[1] JT Inc, Cent Pharmaceut Res Inst, Takatsuki, Osaka 5691125, Japan

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2001年 / 11卷 / 05期

关键词：

cholesteryl ester transfer protein (CETP); high-density lipoprotein (HDL); coronary heart disease (CHD); reverse cholesterol transport (RCT);

D O I：

10.1517/13543776.11.5.739

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As well as hypercholesterolaemia, low levels of high-density lipoprotein cholesterol (HDL;C) are critical risk factors for atherosclerosis and coronary heart disease (CHD). Although fibrate, simvastatin and niacin can be used for the treatment of a low HDL-C level, their effects, however, are not wholly satisfactory. Thus, better drugs for the elevation of HDL-C are desired. Among the many methods that mag; be used to raise HDL-C levels, this review focuses on small molecule inhibitors of cholesteryl ester transfer protein (CETP) and summarises recent patent and journal data.

引用

页码：739 / 745

页数：7

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