Strategies for the use of mixture-based synthetic combinatorial libraries: Scaffold ranking, direct testing, in vivo, and enhanced deconvolution by computational methods

被引：98

作者：

Houghten, Richard A. ^{[1
]}

Pinilla, Clernencia ^{[1
]}

Giulianotti, Marc A. ^{[1
]}

Appel, Jon R. ^{[1
]}

Dooley, Colette T. ^{[1
]}

Nefzi, Adel ^{[1
]}

Ostresh, John M. ^{[1
]}

Yu, Yongping ^{[1
]}

Maggiora, Gerald M. ^{[2
]}

Medina-Franco, Jose L. ^{[2
]}

Brunner, Daniela ^{[3
]}

Schneider, Jeff ^{[3
,4
]}

机构：

[1] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA

[2] Univ Arizona, BIO5 Inst & Coll Pharm, Tucson, AZ 85721 USA

[3] PsychoGen Inc, Tarrytown, NY 10591 USA

[4] Carnegie Mellon Univ, Sch Comp Sci, Pittsburgh, PA 15213 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2008年 / 10卷 / 01期

关键词：

D O I：

10.1021/cc7001205

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

[No abstract available]

引用

页码：3 / 19

页数：17

共 83 条

[1] Trimers of N-alkylglycines are potent modulators of the multidrug resistance phenotype [J].

Abad-Merin, MJ ;

Cortés, N ;

Masip, I ;

Pérez-Payá, E ;

Ferragut, JA ;

Messeguer, A ;

Ferrer-Montiel, A .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 313 (01) :112-120

[2] A constant time algorithm for estimating the diversity of large chemical libraries [J].

Agrafiotis, DK .

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 2001, 41 (01) :159-167

[3] Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells [J].

Berezovskaya, O ;

Schimmer, AD ;

Glinskii, AB ;

Pinilla, C ;

Hoffman, RM ;

Reed, JC ;

Glinsky, GV .

CANCER RESEARCH, 2005, 65 (06) :2378-2386

[4] Simultaneous pharmacokinetic screening of a mixture of compounds in the dog using API LC/MS/MS analysis for increased throughput [J].

Berman, J ;

Halm, K ;

Adkison, K ;

Shaffer, J .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (06) :827-829

[5] Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides for defining substrate specificity of the angiotensin I-converting enzyme and development of selective C-domain substrates [J].

Bersanetti, PA ;

Andrade, MCC ;

Casarini, DE ;

Juliano, MA ;

Nchinda, AT ;

Sturrock, ED ;

Juliano, L ;

Carmona, AK .

BIOCHEMISTRY, 2004, 43 (50) :15729-15736

[6] Solution-phase combinatorial libraries: Modulating cellular signaling by targeting protein-protein or protein-DNA interactions [J].

Boger, DL ;

Desharnais, J ;

Capps, K .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (35) :4138-4176

[7] Reversible inhibitors of λ integrase-mediated recombination efficiently trap Holliday junction intermediates and form the basis of a novel assay for junction resolution [J].

Boldt, JL ;

Pinilla, C ;

Segall, AM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (05) :3472-3483

[8]

BRUNNER D, 2007, Patent No. 7269516

[9] T cell activity correlates with oligomeric peptide-major histocompatibility complex binding on T cell surface [J].

Buslepp, J ;

Zhao, R ;

Donnini, D ;

Loftus, D ;

Saad, M ;

Appella, E ;

Collins, EJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (50) :47320-47328

[10] Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization [J].

Capps, KJ ;

Humiston, J ;

Dominique, R ;

Hwang, I ;

Boger, DL .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (11) :2840-2844

← 1 2 3 4 5 6 7 8 9 →