A new stereospecific synthesis of unusual (Z)-β-branched Baylis-Hillman adducts

被引：47

作者：

Li, GG ^{[1
]}

Wei, HX ^{[1
]}

Willis, S ^{[1
]}

机构：

[1] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(98)00850-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method has been developed for the stereospecific synthesis of unusual (Z)-beta-branched Baylis-Hillman adducts with high Z/E selectivity (>99 %) in modest to good yields. The process involves successful formation of anionic beta-substituted [alpha-(alkoxycarbonyl)vinyl]aluminum intermediates and their coupling with aldehydes and ketones catalyzed by n-Bu2BOTf at -78 degrees C. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4607 / 4610

页数：4

共 15 条

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