Detection, evaluation, and management of iron-restricted erythropoiesis
被引:296
作者:
Goodnough, Lawrence Tim
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机构:
Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USAStanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
Goodnough, Lawrence Tim
[1
,2
]
Nemeth, Elizabeta
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机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol, Los Angeles, CA 90095 USAStanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
Nemeth, Elizabeta
[3
,4
]
Ganz, Tomas
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h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol, Los Angeles, CA 90095 USAStanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
Ganz, Tomas
[3
,4
]
机构:
[1] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol, Los Angeles, CA 90095 USA
Progress in our understanding of iron-restricted erythropoiesis has been made possible by important advances in defining the molecular mechanisms of iron homeostasis. The detection and diagnostic classification of iron-restricted erythropoiesis can be a challenging process for the clinician. Newer assays for markers of inflammation may allow more targeted management of the anemia in these conditions. The availability of new intravenous iron preparations provides new options for the treatment of iron-restricted erythropoiesis. This review summarizes recent advances regarding the detection, evaluation, and management of iron-restricted erythropoiesis. (Blood. 2010;116(23):4754-4761)