Synthesis and biological evaluation of unnatural canthine alkaloids

被引：36

作者：

Lindsley, CW

Bogusky, MJ

Leister, WH

McClain, RT

Robinson, RG

Barnett, SF

Defeo-Jones, D

Ross, CW

Hartman, GD

机构：

[1] Merck & Co Inc, Merck Res Labs, Dept Med Chem, Enabled Synth Grp, W Point, PA 19486 USA

[2] Merck & Co Inc, Merck Res Labs, Dept Canc Res, W Point, PA 19486 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 16期

关键词：

D O I：

10.1016/j.tetlet.2005.02.143

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Employing a ' one-pot ' microwave-assisted protocol, unnatural canthine alkaloids with biological activities beyond the natural products have been prepared. This report describes unnatural canthine alkaloid analogs as selective, allosteric Akt kinase inhibitors. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：2779 / 2782

页数：4

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