Fluorous-tethered quenching reagents for solution phase parallel synthesis

被引：41

作者：

Lindsley, CW ^{[1
]}

Zhao, Z ^{[1
]}

Leister, WH ^{[1
]}

机构：

[1] Merck Res Labs, Dept Med Chem, Technol Enabled Synth Grp, W Point, PA 19486 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 23期

关键词：

combinatorial chemistry; fluorine and compounds;

D O I：

10.1016/S0040-4039(02)00748-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Commercially available fluorous-tethered reagents are employed to quench excess reactants and remove known impurities from crude reaction mixtures generated via solution phase parallel synthesis. Fluorous quenching reagents are expediently removed via FluoroFlash((TM)) SPE columns to afford products in high yields and purities. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：4225 / 4228

页数：4

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