Bronsted acid-catalyzed desymmetrization of meso-aziridines

被引：192

作者：

Rowland, Emily B. ^{[1
]}

Rowland, Gerald B. ^{[1
]}

Rivera-Otero, Edwin ^{[1
]}

Antilla, Jon C. ^{[1
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 40期

关键词：

D O I：

10.1021/ja0751779

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective ring-opening of meso-aziridines with azide nucleophiles; proceeded in the presence of a catalytic amount of a chiral phosphoric acid catalyst. The reaction affords the formation of the products in excellent yield and enantioselectivity. Preliminary mechanistic studies indicate that the active catalytic species is a chiral silane that is generated in situ.

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页码：12084 / +

页数：3

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