Endomorphins have orexigenic and anxiolytic activities in mice

被引：89

作者：

Asakawa, A

Inui, A

Momose, K

Ueno, N

Fujino, MA

Kasuga, M

机构：

[1] Kobe Univ, Sch Med, Dept Internal Med 2, Chuo Ku, Kobe, Hyogo 650, Japan

[2] Yamanashi Med Univ, Dept Internal Med 1, Nakakoma, Yamanashi 40938, Japan

来源：

NEUROREPORT | 1998年 / 9卷 / 10期

关键词：

anxiolytic; endomorphins; 1; and; 2; feeding; intracerebroventricular; mice; mu-opioid receptor;

D O I：

10.1097/00001756-199807130-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THIS study was designed to investigate the effects of endomorphin 1 and 2, recently identified mu-opioid receptor selective peptides, on food intake and anxiety in non-food-deprived mice. The intracerebroventricular (i.c.v.) injection of either endomorphin 1 or 2 (0.03-30 nmol) increased food intake in a dose-related manner. A significant increase was observed 20 min after i.c.v. injection of endomorphin 1 dr 2 and continued for 4 h. In the elevated plus maze test, the i.c.v. injection of endomorphin 1 (30 nmol) significantly decreased the normal preference for the closed arms. These results suggest that endomorphin produces orexigenic and anxiolytic effects, and that the mu-opioid receptor contributes to the regulation of feeding and anxiety in mice. Neuro Report 9: 2265-2267 (C) 1998 Rapid Science Ltd.

引用

页码：2265 / 2267

页数：3

共 18 条

[1] The endogenous mu-opioid receptor agonists endomorphins 1 and 2 have novel hypotensive activity in the rabbit [J].