Constituents of tropical medicinal plants.: Part 87 -: Rosane diterpenes and bis-dinorditerpenes from Hugonia casteneifolia

被引：23

作者：

Mdee, LK

Waibel, R

Nkunya, MHH

Jonker, SA

Achenbach, H ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Pharmaceut Chem, Inst Pharm & Food Chem, D-90152 Erlangen, Germany

[2] Univ Dar Es Salaam, Dept Chem, Dar Es Salaam, Tanzania

来源：

PHYTOCHEMISTRY | 1998年 / 49卷 / 04期

关键词：

Hugonia casteneifolia; Linaceae; diterpenes; hugorosenone; 18-hydroxyhugorosenone; hugorosediol; hugonone A; hugonone B;

D O I：

10.1016/S0031-9422(97)01037-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From the root bark of Hugonia casteneifolia three new rosane-type diterpenes, hugorosenone (3 beta-hydroxy-1(10),15-rosadien-2-one), 18-hydroxyhugorosenone (3 beta, 18-dihydroxy-1(10),15-rosadien-2-one), hugo-rosediol (3 beta,18-dihydroxy-1(10), 15-rosadiene), and the two bis-dinorditerpenes, hugonone A and hugonone B, have been isolated. Structural determination was achieved by spectroscopic methods. Extracts of the root bark exhibited cytotoxic activity in the brine shrimp bioassay, and hugorosenone was demonstrated to be the corresponding active principle. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1107 / 1113

页数：7

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