Partial volume effect compensation for quantitative brain SPECT imaging

被引:95
作者
Du, Y [1 ]
Tsui, BMW [1 ]
Frey, EC [1 ]
机构
[1] Johns Hopkins Univ, Dept Radiol, Baltimore, MD 21287 USA
关键词
brain SPECT imaging; partial volume effect compensation; quantification;
D O I
10.1109/TMI.2005.850547
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
Partial volume (PV) effects degrade the quantitative accuracy of SPECT brain images. In this paper, we extended a PV compensation (PVC) method originally developed for brain PET, the geometric transfer matrix (GTM) method, to brain SPECT using iterative reconstruction-based compensations. In the GTM method a linear transform between the true regional activities and the measured results was assumed. Elements of the GTM were calculated by projecting and reconstructing maps with uniform regions representing different structures. However, with iterative reconstruction methods, especially when reconstruction-based compensation for detector response was applied, we found that it was important to treat the region maps as a perturbation to the reconstructed image in the estimation of the GTM. This modified method, termed perturbation-based GTM (pGTM) was evaluated using Monte Carlo (MC) simulated and experimentally acquired data. Results showed great improvement of the quantitative accuracy in brain SPECT imaging. For MC simulated data, PVC using pGTM reduced the underestimation of striatal activities from 30% to less than 1.2%. For experimental data, PVC using pGTM reduced the underestimation of striatal activities from 36% to less than 7.8%. The underestimation of the striatum to background activity ratio was also improved from 31% to 2.7%.
引用
收藏
页码:969 / 976
页数:8
相关论文
共 34 条
[11]   ACCELERATED IMAGE-RECONSTRUCTION USING ORDERED SUBSETS OF PROJECTION DATA [J].
HUDSON, HM ;
LARKIN, RS .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 1994, 13 (04) :601-609
[12]  
Iida H, 1998, J NUCL MED, V39, P181
[13]   PHYSICAL FACTORS AFFECTING QUANTITATIVE MEASUREMENTS USING CAMERA-BASED SINGLE PHOTON-EMISSION COMPUTED-TOMOGRAPHY (SPECT) [J].
JASZCZAK, RJ ;
COLEMAN, RE ;
WHITEHEAD, FR .
IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 1981, 28 (01) :69-80
[14]   Fast implementations of reconstruction-based scatter compensation in fully 3D SPECT image reconstruction [J].
Kadrmas, DJ ;
Frey, EC ;
Karimi, SS ;
Tsui, BMW .
PHYSICS IN MEDICINE AND BIOLOGY, 1998, 43 (04) :857-873
[15]  
Kim KM, 2003, J NUCL MED, V44, P512
[16]  
Links JM, 1998, Q J NUCL MED, V42, P158
[17]   THE CONVERGENCE OF OBJECT DEPENDENT RESOLUTION IN MAXIMUM-LIKELIHOOD BASED TOMOGRAPHIC IMAGE-RECONSTRUCTION [J].
LIOW, JS ;
STROTHER, SC .
PHYSICS IN MEDICINE AND BIOLOGY, 1993, 38 (01) :55-70
[18]  
Matsuda H, 2003, J NUCL MED, V44, P1243
[19]   THE GEOMETRIC TRANSFER-FUNCTION COMPONENT FOR SCINTILLATION CAMERA COLLIMATORS WITH STRAIGHT PARALLEL HOLES [J].
METZ, CE ;
ATKINS, FB ;
BECK, RN .
PHYSICS IN MEDICINE AND BIOLOGY, 1980, 25 (06) :1059-1070
[20]   Influence of OSEM, elliptical orbits and background activity on SPECT 3D resolution recovery [J].
Pan, TS ;
Luo, DS ;
Kohli, V ;
King, MA .
PHYSICS IN MEDICINE AND BIOLOGY, 1997, 42 (12) :2517-2529