The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved

被引：17

作者：

Deltour, S ^{[1
]}

Guerardel, C ^{[1
]}

Stehelin, D ^{[1
]}

Leprince, D ^{[1
]}

机构：

[1] Inst Pasteur, Inst Biol Lille, CNRS URA 1160, F-59021 Lille, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1443卷 / 1-2期

关键词：

HIC-1; BTB/POZ; zinc finger; tumor suppressor gene; 17p13.3;

D O I：

10.1016/S0167-4781(98)00219-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HIC-1 (hypermethylated in cancer), a new candidate tumor suppressor gene located in 17p13.3, encodes a protein with five Kruppel-like C2H2 zinc finger motifs and a N-terminal protein-protein interaction domain called BTB/POZ. These two domains appeared as the only conserved regions found between human HIC-1 and its avian homologue, gamma FBP-B, isolated as a transcriptional repressor of the gamma F-Crystallin gene. We have recloned the HIC-1 gene and found four nucleotide differences within the 3' part of its published coding sequence. The corrected HIC-1 C-terminal end exhibits now significant homology (70%) to the chicken gamma FBP-B C-terminal end and appears thus as a third phylogenetically conserved domain that may serve an important, yet unknown function in HIC-1. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：230 / 232

页数：3