The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

被引：2351

作者：

Mihaylova, Maria M. ^{[1
]}

Shaw, Reuben J. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Howard Hughes Med Inst, Mol & Cell Biol Lab, La Jolla, CA 92037 USA

来源：

NATURE CELL BIOLOGY | 2011年 / 13卷 / 09期

关键词：

ACTIVATED PROTEIN-KINASE; ELEMENT-BINDING PROTEIN; GENE-EXPRESSION; DIRECT PHOSPHORYLATION; FATTY-ACID; HISTONE DEACETYLASES; TRANSCRIPTION FACTOR; HEPATIC STEATOSIS; UPSTREAM KINASE; SKELETAL-MUSCLE;

D O I：

10.1038/ncb2329

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases. AMPK has critical roles in regulating growth and reprogramming metabolism, and has recently been connected to cellular processes such as autophagy and cell polarity. Here we review a number of recent breakthroughs in the mechanistic understanding of AMPK function, focusing on a number of newly identified downstream effectors of AMPK.

引用

页码：1016 / 1023

页数：8

共 128 条

[81] Autophagy fights disease through cellular self-digestion [J].

Mizushima, Noboru ;

Levine, Beth ;

Cuervo, Ana Maria ;

Klionsky, Danial J. .

NATURE, 2008, 451 (7182) :1069-1075

[82] Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells [J].

Nakada, Daisuke ;

Saunders, Thomas L. ;

Morrison, Sean J. .

NATURE, 2010, 468 (7324) :653-U69

[83] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation [J].

Nakano, Atsushi ;

Kato, Hisakazu ;

Watanabe, Takashi ;

Min, Kyung-Duk ;

Yamazaki, Satoru ;

Asano, Yoshihiro ;

Seguchi, Osamu ;

Higo, Shuichiro ;

Shintani, Yasunori ;

Asanuma, Hiroshi ;

Asakura, Masanori ;

Minamino, Tetsuo ;

Kaibuchi, Kozo ;

Mochizuki, Naoki ;

Kitakaze, Masafumi ;

Takashima, Seiji .

NATURE CELL BIOLOGY, 2010, 12 (06) :583-U139

[84] Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival [J].

Narbonne, Patrick ;

Roy, Richard .

NATURE, 2009, 457 (7226) :210-U108

[85] AMPK and PPARδ Agonists are exercise mimetics [J].

Narkar, Vihang A. ;

Downes, Michael ;

Yu, Ruth T. ;

Embler, Emi ;

Wang, Yong-Xu ;

Banayo, Ester ;

Mihaylova, Maria M. ;

Nelson, Michael C. ;

Zou, Yuhua ;

Juguilon, Henry ;

Kang, Heonjoong ;

Shaw, Reuben J. ;

Evans, Ronald M. .

CELL, 2008, 134 (03) :405-415

[86] PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila [J].

Nishimura, I ;

Yang, YF ;

Lu, BW .

CELL, 2004, 116 (05) :671-682

[87] AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase [J].

Oakhill, Jonathan S. ;

Steel, Rohan ;

Chen, Zhi-Ping ;

Scott, John W. ;

Ling, Naomi ;

Tam, Shanna ;

Kemp, Bruce E. .

SCIENCE, 2011, 332 (6036) :1433-1435

[88] β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK) [J].

Oakhill, Jonathan S. ;

Chen, Zhi-Ping ;

Scott, John W. ;

Steel, Rohan ;

Castelli, Laura A. ;

Ling, Naomi ;

Macaulay, S. Lance ;

Kemp, Bruce E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (45) :19237-19241

[89] SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1 [J].

Pacholec, Michelle ;

Bleasdale, John E. ;

Chrunyk, Boris ;

Cunningham, David ;

Flynn, Declan ;

Garofalo, Robert S. ;

Griffith, David ;

Griffor, Matt ;

Loulakis, Pat ;

Pabst, Brandon ;

Qiu, Xiayang ;

Stockman, Brian ;

Thanabal, Venkataraman ;

Varghese, Alison ;

Ward, Jessica ;

Withka, Jane ;

Ahn, Kay .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (11) :8340-8351

[90] SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth [J].

Porstmann, Thomas ;

Santos, Claudio R. ;

Griffiths, Beatrice ;

Cully, Megan ;

Wu, Mary ;

Leevers, Sally ;

Griffiths, John R. ;

Chung, Yuen-Li ;

Schulze, Almut .

CELL METABOLISM, 2008, 8 (03) :224-236

← 4 5 6 7 8 9 10 11 12 13 →