Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving oxcarbazepine

被引：17

作者：

Cansu, Ali ^{[1
]}

Serdaroglu, Ayse ^{[2
]}

Cinaz, Peyami ^{[3
]}

机构：

[1] Karadeniz Tech Univ, Dept Pediat Neurol, Fac Med, TR-61080 Trabzon, Turkey

[2] Gazi Univ, Dept Pediat Neurol, Fac Med, Ankara, Turkey

[3] Gazi Univ, Dept Pediat Endocrinol, Fac Med, Ankara, Turkey

来源：

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | 2011年 / 15卷 / 06期

关键词：

Oxcarbazepine; Leptin; Neuropeptide Y; Galanin; Ghrelin; ANTIEPILEPTIC DRUGS; VALPROIC ACID; TURKISH CHILDREN; PUBERTAL CHANGES; THYROID-FUNCTION; CARBAMAZEPINE; GROWTH; GIRLS; OBESITY; WEIGHT;

D O I：

10.1016/j.ejpn.2011.05.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Purpose: The aim of this study was to investigate whether oxcarbazepine (OXC) monotherapy causes weight gain in epileptic children. Methods: A total of 22 children with epilepsy (age 3.0-16.4 years) were assigned to OXC therapy. Serum levels of glucose, insulin, cortisol, leptin, neuropeptide Y (NPY), galanin and ghrelin were assessed before OXC therapy (month 0) and after the 6th and 18th months. Results: There was no statistically significant difference in weight-standard deviation score (SDS), Height-SDS, BMI-SDS, serum glucose, insulin, cortisol, leptin, NPY, galanin and ghrelin levels between initial values (month 0) and those in the 6th and 18th months after OXC therapy (p > 0.05). Conclusions: Our results indicate that OXC therapy causes neither weight change nor alterations in serum glucose, insulin, cortisol, leptin, NPY, galanin and ghrelin levels in children with epilepsy. (C) 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights. reserved.

引用

页码：527 / 531

页数：5

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