Peroxisome proliferator-activated receptor-γ:: too much of a good thing causes harm

被引：119

作者：

Cock, TA

Houten, SM

Auwerx, J

机构：

[1] Univ Strasbourg 1, CNRS, INSERM, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

[2] Genopole Strasbourg, Inst Clin Souris, F-67404 Illkirch Graffenstaden, France

来源：

EMBO REPORTS | 2004年 / 5卷 / 02期

关键词：

atherosclerosis; integrated metabolism; longevity; mouse models; obesity;

D O I：

10.1038/sj.embor.7400082

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) helps to translate 'what you eat' into 'what you are' because it allows dietary fatty acids (PPARgamma ligands) to modulate gene transcription. Treatments for diabetes include PPARgamma activators, as they sensitize the body to insulin. Our understanding of PPARgamma function has recently been enhanced by a flurry of human and mouse genetic studies, and the characterization of new PPARgamma ligands. This insight has led us to propose that modulating PPARgamma activity, rather than activating it, might be the most effective strategy for treating metabolic disorders, as this will improve glucose homeostasis while preventing adipogenesis.

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页码：142 / 147

页数：6

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