pH-Induced Shape-Memory Polymers

被引：327

作者：

Han, Xiao-Juan ^{[2
]}

Dong, Zhen-Qiang ^{[2
]}

Fan, Min-Min ^{[2
]}

Liu, Yan ^{[2
]}

Li, Jian-Hu ^{[2
]}

Wang, Yi-Fu ^{[2
]}

Yuan, Qi-Juan ^{[2
]}

Li, Bang-Jing ^{[1
]}

Zhang, Sheng ^{[2
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

[2] Sichuan Univ, State Key Lab Polymer Mat Engn, Polymer Res Inst, Chengdu 610065, Peoples R China

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2012年 / 33卷 / 12期

基金：

中国国家自然科学基金;

关键词：

biocompatibility; cyclodextrin; host-guest systems; pH sensitive; shape memory; POLYPSEUDOROTAXANE FORMATION; SENSITIVE HYDROGEL; ALPHA-CYCLODEXTRIN; DRUG-DELIVERY; ALGINATE; DEPENDENCE; MEDICINE;

D O I：

10.1002/marc.201200153

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

A novel pH sensitive shape-memory polymer (SMP) is prepared by cross-linking the beta-cyclodextrin modified alginate (beta-CD-Alg) and diethylenetriamine modified alginate (DETA-Alg): The pH reversible beta-CD-DETA inclusion complexes serve as a reversible phase, and the cross-linked alginate chains serve as a fixing phase. It is shown that this material can be processed into temporary shape as we needs at pH 11.5 and recover to its initial shape at pH 7. The recovery ratio and the fixity ratio were 95.7 +/- 0.9% and 94.8 +/- 1.1%, respectively. Furthermore, this material showed good degradability and biocompatibility. Because the shape transition pH value is quite close to that of our body fluid and this pH triggered shape-memory effect is convenient and safe to use, this material has a high potential for medical application.

引用

页码：1055 / 1060

页数：6

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