Investigation of the effects of tianeptine and fluoxetine on pentylenetetrazole-induced seizures in rats

被引:34
作者
Ceyhan, M [1 ]
Kayir, H [1 ]
Uzbay, IT [1 ]
机构
[1] Gulhane Mil Med Acad, Fac Med, Dept Med Pharmacol, Psychopharmacol Res Unit, TR-06018 Ankara, Turkey
关键词
fluoxetine; pentylenetetrazole (PTZ); rat(s); seizure; tianeptine;
D O I
10.1016/j.jpsychires.2004.06.002
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The effects of tianeptine and fluoxetine on pentylenetetrazole (PTZ)-induced seizures in rats were investigated. Female Wistar rats (172-278 g) were used in the study. Tianeptine (1.25, 2.5, 5, 10 and 20 mg/kg) and fluoxetine (2.5, 5, 10 and 20 mg/kg) or saline were injected to rats intraperitoneally 30 min before PTZ (50 mg/kg) injections. Immediately after PTZ administrations, latency and intensity of the PTZ-induced seizures was recorded and scored, respectively. Fluoxetine (2.5-20 mg/kg) did not produce any significant difference in latency and intensity of the PTZ-induced seizures. Although tianeptine (1.25-20 mg/kg) also did not affect the latency time, it produced significant attenuations in the intensity of the seizures. Tianeptine did not cause any significant change in the locomotor activity of the rats. The results of this preliminary study suggest that tianeptine but not fluoxetine has some inhibitory effects on PTZ-induced seizures in rats. (c) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:191 / 196
页数:6
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