Influence of cholesterol on the bilayer properties of monounsaturated phosphatidylcholine unilamellar vesicles

被引：82

作者：

Kucerka, N. ^{[1
]}

Pencer, J.

Nieh, M.-P.

Katsaras, J.

机构：

[1] CNR, Canadian Neutron Beam Ctr, Chalk River, ON K0J 1P0, Canada

[2] Comenius Univ, Fac Pharm, Dept Phys Chem Drugs, Bratislava 83232, Slovakia

[3] Univ Guelph, Guelph Waterloo Phys Inst, Guelph, ON N1G 2W1, Canada

[4] Univ Guelph, Biophys Interdepartmental Grp, Guelph, ON N1G 2W1, Canada

[5] Brock Univ, Dept Phys, St Catharines, ON L2S 3A1, Canada

来源：

EUROPEAN PHYSICAL JOURNAL E | 2007年 / 23卷 / 03期

关键词：

D O I：

10.1140/epje/i2007-10202-8

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The influence of cholesterol on the structure of unilamellar-vesicle (ULV) phospholipid bilayers is studied using small-angle neutron scattering. ULVs made up of short-, mid- and long-chain monounsaturated phospholipids (diCn :1PC, n = 14 , 18, 22, respectively) are examined over a range (0-45mol %) of cholesterol concentrations. Cholesterol's effect on bilayer structure is characterized through changes to the lipid's transmembrane thickness, lateral area and headgroup hydration. For all three lipids, analysis of the experimental data shows that the addition of cholesterol results in a monotonic increase of these parameters. In the case of the short- and mid-chain lipids, this is an expected result, however, such a finding was unexpected for the long-chain lipid. This implies that cholesterol has a pronounced effect on the lipid's hydrocarbon chain organization.

引用

页码：247 / 254

页数：8

共 53 条

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