Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

被引：97

作者：

Balducci, Chiara

Pierguidi, Laura

Persichetti, Emanuele

Parnetti, Lucilla

Sbaragli, Michele

Tassi, Carmelo

Orlacchio, Aldo

Calabresi, Paolo

Beccari, Tommaso

Rossi, Aroldo

机构：

[1] Univ Perugia, Dipartimento Med Interna, I-06126 Perugia, Italy

[2] Univ Perugia, Neurol Clin, Osped Santa Maria della Misericordia, I-06126 Perugia, Italy

[3] Fdn Santa Lucia, IRCCS, Rome, Italy

[4] Univ Perugia, Dipartimento Med Sperimentale & Sci Biochim, I-06126 Perugia, Italy

来源：

MOVEMENT DISORDERS | 2007年 / 22卷 / 10期

关键词：

Parkinson's disease; beta-glucocerebrosidase; alpha-mannosidase; beta-mannosidase; beta-hexosaminidase;

D O I：

10.1002/mds.21399

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of beta-glucocerebrosidase and the activities of other lysosomal enzymes, alpha-mannosidase, beta-mannosidase, beta-hexosaminidase, and beta-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of alpha-mannosidase, beta-mannosidase, beta-glueocerebrosidase, and beta-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of beta-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. (c) 2007 Movement Disorder Society.

引用

页码：1481 / 1484

页数：4

共 15 条

[1] β-hexosaminidase, α-D-mannosidase, and β-mannosidase expression in serum from patients with carbohydrate-deficient glycoprotein syndrome type I [J].