Synergistic cooperation between water-soluble chitosan oligomers and interferon-γ for induction of nitric oxide synthesis and tumoricidal activity in murine peritoneal macrophages

被引：120

作者：

Seo, WG

Pae, HO

Kim, NY

Oh, GS

Park, IS

Kim, YH

Kim, YM

Lee, Y

Jun, CD

Chung, HT ^{[1
]}

机构：

[1] Wonkwang Univ, Sch Med, Dept Microbiol & Immunol, Chonbuk 570749, South Korea

[2] Wonkwang Univ, Med Resources Res Ctr, Chonbuk 570749, South Korea

来源：

CANCER LETTERS | 2000年 / 159卷 / 02期

关键词：

chitosan oligomers; nitric oxide; tumor necrosis factor-alpha; tumoricidal activity; macrophages;

D O I：

10.1016/S0304-3835(00)00551-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The effects of water-soluble chitosan oligomers (WSCO) on the synthesis of nitric oxide (NO) by murine peritoneal macrophages and on macrophage-mediated cytotoxicity towards murine fibrosarcoma Meth A cells were investigated. WSCO alone had no effect on NO synthesis and killing of tumor cells. However, treatment of macrophages with a combination of WSCO and interferon-gamma (IFN-gamma) synergically increased NO synthesis and enhanced killing of tumor cells. The synergism between IFN-gamma, and WSCO in NO synthesis and tumoricidal activity was mainly dependent on increased secretion of tumor necrosis factor-alpha by WSCO. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：189 / 195

页数：7

共 13 条

[1]

A novel method for chemo-enzymatic synthesis of elicitor-active chitosan oligomers and partially N-deacetylated chitin oligomers using N-acylated chitotrioses as substrates in a lysozyme-catalyzed transglycosylation reaction system [J].