Physical map of the HLA-A/HLA-F subregion and identification of two new coding sequences

被引：16

作者：

Pichon, L ^{[1
]}

Giffon, T ^{[1
]}

Chauvel, B ^{[1
]}

Carn, G ^{[1
]}

Bouric, P ^{[1
]}

ElKahloun, A ^{[1
]}

Legall, JY ^{[1
]}

David, V ^{[1
]}

机构：

[1] RECOMBINAISONS GENET FAC MED, DEPT BIOCHEM & MOLEC BIOL, UPR CNRS 41, F-35043 RENNES, FRANCE

来源：

IMMUNOGENETICS | 1996年 / 43卷 / 04期

关键词：

CLASS-I REGION; MAJOR HISTOCOMPATIBILITY COMPLEX; ARTIFICIAL CHROMOSOME CLONES; HUMAN MHC; HEMOCHROMATOSIS GENE; GEL-ELECTROPHORESIS; GENOMIC STRUCTURE; DNA-SEQUENCES; A LOCUS; YEAST;

D O I：

10.1007/BF00587297

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

As part of an effort to characterize the hemochromatosis gene, we selected three non-chimeric yeast artificial chromosomes (YACs) overlapping with the YAC B30 previously described and forming an 800 kilobase contig covering the HLA-A/HLA-F region. The precise physical map of these YACs and of the corresponding genomic region were established. Nine concentrated sites of CpG cutter elements, potentially HTF islands, were mapped. In addition, several probes have been generated as tools for mapping and examining transcripts produced in the region. This allowed for the characterization and localization of two new coding sequences, provisionally named HCG (for hemochromatosis candidate gene) and numbered VIII and IX.

引用

页码：175 / 181

页数：7

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