Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats

被引：131

作者：

Chen, Zhi-peng ^{[1
]}

Sun, Jun ^{[1
]}

Chen, Hong-xuan ^{[2
]}

Xiao, Yan-yu ^{[3
]}

Liu, Dan ^{[3
]}

Chen, Jun ^{[1
]}

Cai, Hao ^{[1
]}

Cai, Bao-chang ^{[1
]}

机构：

[1] Nanjing Univ Tradit Chinese Med, Dept Pharm, Nanjing 210046, Peoples R China

[2] Henan Univ, Dept Pharm, Kaifeng 475001, Peoples R China

[3] China Pharmaceut Univ, Pharmaceut Res Inst, Nanjing 210009, Peoples R China

来源：

FITOTERAPIA | 2010年 / 81卷 / 08期

关键词：

Ginkgo biloba extracts; Quercetin; Kaempferol; Isorhamnetin; Pharmacokinetics; Bioavailability; CARDIOPROTECTIVE ACTIVITY; ANTIOXIDANT ACTIVITY; PHYTOSOMES; PLASMA; CURCUMIN;

D O I：

10.1016/j.fitote.2010.06.028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of this study was to improve the oral bioavailability of Ginkgo biloba extract (GBE) through preparing G. biloba extract phospholipid complexes (GBP) and G. biloba extract solid dispersions (CBS). Firstly we prepared the GBP and GBS and studied their physicochemical properties by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD) and dissolution. Then we studied the pharmacokinetic characteristics and bioavailability in rats. The results showed that the bioavailability of quercetin, kaempferol and isorhamnetin in rats was increased remarkably after oral administration of GBP and GBS comparing with GBE. The bioavailabilities of GBP increased more than that of GBS. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1045 / 1052

页数：8

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